Santanam is the story of Laxmi, Ramu and Babu the three sibblings, whose mother died immidiately after delivering Babu. Their father (S.V.Ranga Rao) couldn't handle the poverty and in order to earn more money he works continously and losses his eye sight and leaves the house. All the three children, not able to pay the rent, leaves the house. While travelling in a train, Laxmi and Babu sits together but Ramu is somewhere else and they got seperated. Laxmi starts living in Mohan's house whereas Babu is been kidnapped but had been saved again by a man. Here Ramu joins in with a drama company. All the three had been seperated and starts to live their lives. But one fine day all the three reunites again. How did this happen?