托比·马奎尔

Tobey Maguire

饰：蜘蛛侠 Spider-Man,Peter Parker

克尔斯滕·邓斯特

Kirsten Dunst

饰：简 Mary Jane Watson

詹姆斯·弗兰科

James Franco

饰：哈利 Harry Osborn

阿尔弗雷德·莫里纳

Alfred Molina

饰：欧科博士Doc Ock,Dr. Otto Octavius

罗斯玛丽·哈里斯

Rosemary Harris

饰：梅 May Parker

J·K·西蒙斯

J.K. Simmons

饰：壮 J. Jonah Jameson

唐娜·墨菲

Donna Murphy

饰：罗莎莉屋大维 Rosalie Octavius

丹尼尔·吉里斯

Daniel Gillies

饰：约翰·詹姆森 John Jameson

迪伦·贝克

Dylan Baker

饰：蜥蜴人 Dr. Curt Connors

比尔·努恩

Bill Nunn

饰：Joseph 'Robbie' Robertson

范妮莎·费丽托

Vanessa Ferlito

饰：Louise

阿西夫·曼德维

Aasif Mandvi

饰：Mr. Aziz

威廉·达福

Willem Dafoe

饰：Green Goblin,Norman Osborn

克里夫·罗伯逊

Cliff Robertson

饰：Ben Parker

泰德·雷米

Ted Raimi

饰：Hoffman

伊丽莎白·班克斯

Elizabeth Banks

饰：Miss Brant

布鲁斯▪坎贝尔

Bruce Campbell

饰：Snooty Usher

格雷格·埃德尔曼

Gregg Edelman

饰：Dr. Davis

埃利亚·巴斯金

Elya Baskin

饰：Mr. Ditkovich

马吉纳·托娃

Mageina Tovah Mageina Tovah Begtrup

饰：Ursula

金大贤

Daniel Dae Kim

饰：Raymond

哈尔·斯帕克斯

Hal Harry Magee Sparks

饰：Elevator Passenger

乔尔·麦克哈尔

Joel Edward Mchale

饰：Mr. Jacks

斯坦·李

Stan Lee

饰：Man Dodging Debris

布兰特·布里斯科

Brent Briscoe

饰：Garbage Man

艾米丽·丹斯切尔

Emily Deschanel

饰：Receptionist

斯科特·斯皮格尔

Scott Spiegel

饰：Man on Balcony

Andy Bale

饰：OsCorp Executive (as Andrew Bale)

克里斯汀·艾斯布鲁克

Christine Estabrook

饰：Mrs. Jameson

莫莉·曲克

Molly Cheek

饰：Society Woman

乔伊·布莱恩特

Joy Bryant

饰：Woman at Web

乔安娜·巴隆

Joanne Baron

饰：Skeptical Scientist

皮特·麦克罗比

Peter McRobbie

饰：OsCorp Representative

蒂莫西·杰尔姆

Timothy Jerome

饰：Injured Scientist (as Tim Jerome)

Taylor Gilbert

Taylor Gilbert

饰：Mrs. Watson

路易斯·隆巴迪

Louis Lombardi

饰：Poker Player

马克·约翰·杰弗瑞

Marc John Jefferies

饰：Amazed Kid

里德·戴蒙德

Reed Edward Diamond

饰：Algernon

丹·卡拉汉

Dan Callahan

饰：'Jack'

约翰·兰迪斯

John Landis

饰：Doctor

Tricia Peters

饰：Screaming Nurse

安妮·贝当古

Anne Betancourt

饰：Woman at Fire

Bill E. Rogers

饰：Fireman

乔·沃兹

Joe Virzi

饰：Fireman

Tom Carey

饰：Train Conductor

Peter Allas

Peter Allas

饰：Train Passenger

布兰娜·布朗

Brianna Brown

饰：Train Passenger (as Brianna Lynn Brown)

比尔·卡尔弗特

Bill Calvert

饰：Train Passenger (as William Calvert)

Joey Diaz

Joey Diaz

饰：Train Passenger (as Joey Coco Diaz)

丹·希克斯

Dan Hicks

饰：Train Passenger (as Danny Hicks)

Timothy Patrick Quill

Timothy Patrick Quill

饰：Train Passenger

Jill Sayre

饰：Train Passenger

Damian Bailey

饰：Extra (uncredited)

Frank Bonsangue

Frank Bonsangue

饰：Pizza Man (uncredited)

大卫·波士顿

David Boston

饰：Pedestrian (uncredited)

张欣迪

Cindy Cheung

饰：Chinese Daughter (uncredited)

Vince Capone

Vince Capone

饰：Victim (uncredited)

Barbara Ann Davison

饰：Woman with Dog (uncredited)

卡尔文·迪恩

Calvin Dean

饰：Boomer (uncredited)

法布里奇奥·范特

Fabrizio Fante

饰：Businessman (uncredited)

菲利普·格拉姆

Phillip Gramm

饰：NYPD Officer (uncredited)

Halla

Halla

饰：Wedding Attendee (uncredited)

穆罕默德·哈桑

Mohammed Hassan

饰：Middle Eastern Taxi Driver (uncredited)

Andre M. Johnson

Andre M. Johnson

饰：Fireman 2 (uncredited)

克劳迪娅·卡茨

Claudia Katz

饰：Robbie's Assistant (uncredited)

菲尔·拉马

Phil LaMarr

饰：Train Passenger (uncredited)

露西·劳莱丝

Lucy Lawless

饰：Blonde woman screaming (uncredited)

Frank Langley

Frank Langley

饰：Doc Ock Tentacle Puppeteer (uncredited)

斯宾塞·李斯特

Spencer List

饰：Little Boy Playing on Steps (uncredited)

罗蕾莱·李

Lorelei Llee

饰：Bank Employee (uncredited)

Carina Mastrippolito

饰：Girl (uncredited)

特洛伊·梅特卡夫

Troy Metcalf

饰：Blue Collar Guy (uncredited)

Altara Michelle

饰：Teenage Girl at the Bank (uncredited)

David Orris

饰：Police Officer (uncredited)

Ronn Ozuk

饰：Cop (uncredited)

Christopher Porto

饰：Man Waiting For Train (uncredited)

Welsey Volcy

饰：Columbia University Student (uncredited)

卢·沃尔普

Lou Volpe

饰：Man at Web (uncredited)

Jack Wetherall

饰：Train Passenger (uncredited)

Ken Wharton

饰：Uptight Businessman (uncredited)

Kelly Connell

饰：Dr. Isaacs

Jason Fiore-Ortiz

饰：Henry Jackson

Peter Vouras

饰：Stage Manager

Donnel Rawlings

Donnel Rawlings

饰：Pizza 'Heist' Witness

扎克瑞·罗杰斯

Zachry Rogers

饰：Boy Saved by Spider-Man

Ella Rogers

饰：Girl Saved by Spider-Man

Roshon Fegam

Roshon Fegam

饰：Amazed Kid

布兰登·帕特里克·康纳

Brendan Patrick Connor

饰：Theater Traffic Cop (as Brendan Connor)

Elyse Dinh

饰：Violinist

Tim Storms

饰：Chainsaw Doctor

苏西·帕克

Susie Park

饰：Clawing Nurse

Michael Edward Thomas

饰：Man at Fire

Venus Lam

饰：Child in Burning Building

Jopaul Epp

饰：Boy with Mask

Weston Epp

饰：Boy with Mask

Tony Campisi

Tony Campisi

饰：Train Passenger

克洛伊·戴克斯特拉

Chloe Dykstra

饰：Train Passenger

Simone Gordon

饰：Train Passenger

Julia Max

饰：Train Passenger

Savannah Pope

饰：Train Passenger

Rickey G. Williams

饰：Train Passenger

Dakota Anderson

Dakota Anderson

饰：Mugger 1 (uncredited)

David Blanc

David Blanc

饰：Street Walker (uncredited)

Peter Cincotti

饰：Piano Player in Planetarium (uncredited)

Christina Della Rose

Christina Della Rose

饰：Chainsaw Nurse (unconfirmed) (uncredited)

Edward Johnson

饰：Planetarium (uncredited)

Eileen Kovener

饰：Street Walker (uncredited)

Ismael Moreno

饰：Rescued Crosswalker (uncredited)

Joe Nelson

饰：Extra (uncredited)

文森特·帕斯托

Vincent Pastore

饰：Train Passenger (uncredited)

山姆·雷米

Sam Raimi

饰：University Student (uncredited) (unconfirmed)

瑞秋·罗德里克

Rachelle Roderick

饰：Jane, Engineer (uncredited)

Scott Skversky

饰：Pedestrian (uncredited)

邦妮· 萨默维尔

Bonnie Somerville

饰：Screaming Woman (uncredited)

Doug Swander

饰：Train Passenger (uncredited)

John Thurner

饰：EL Train Passenger (uncredited)

加雷特·瓦伦

Garrett Warren

饰：Bearded Doctor (uncredited)

罗肖恩·费根

Roshon Fegan

饰：Amazed Kid

Vince Cupone

饰：Victim

佩顿·李斯特

Peyton R. List

饰：Little Girl Playing on Steps

金锋

Feng Jin

唐尼尔·琼斯

Donell Jones

饰：Pizza 'Heist' Witness

克里斯汀·斯图尔特

Kristen Stewart